Deanne taylor, PhD


Deanne Taylor, PhD
Director of Bioinformatics
Department of Biomedical and Health Informatics > Children's Hospital of Philadelphia
Research Assistant Professor, Pediartrics
Perelman School of Medicine
University of Pennsylvania



Biomedical researchers plan to create the Pediatric Cell Atlas (PCA), a powerful new resource for fine-grained scientific understanding of human growth and development. Drawing on dramatic recent advances in technology, the Atlas will offer an unprecedented window into the unique biology of children by benchmarking healthy and abnormal tissues at the level of single cells — the basic units of biology...

Historically, researchers have extracted much cellular and genetic data from bulk tissue samples through measuring levels of active genes and proteins. The available bulk data measurements are low-resolution in their ability to capture the diversity of cell types, cell tasks and cell stages. “We can’t assume that all the cells in one tissue, or even one section of a tissue, are doing the same jobs,” said Taylor. “Some cell types, such as stem cells, may be present in very low numbers, but may be performing key tasks. Cells may also perform different tasks at different stages, but these details may be lost in the noise from bulk data.”

Read the article in Genome Web.

Read the full CHOP press release here.

Hear Deanne Taylor interviewed on whyy.org.