CHOP researchers developed computational tool aided by the CHOP Research Institute's Arcus Pediatric Knowledge Network. The article appears in. Pediatric Critical Care Medicine

Philadelphia, February 27, 2020--Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel computational algorithm to track the epidemiology of pediatric sepsis, allowing for the collection of more accurate data about outcomes and incidence of the condition over time, which is essential to the improvement of care.

"Ultimately, researchers would leverage knowledge from single-cell data into a deeper understanding of organ development and function, to better inform precision treatments to advance children’s health,” Deanne Taylor, PhD, DBHi Director of Bioinformatics "

CHOP Clinical Informatics Fellows Tobias and Muthu Take Top Prize National Health Data Challenge

Washington, DC – The “Closing the Data Divide” Virtual Challenge, a nationwide search for technology-based solutions to facilitate data exchange between health care providers and public health agencies, has named a winner: “PHRASE,” or the Population Health Risk Assessment Support Engine. PHRASE was developed by Marc Tobias, MD, and Naveen Muthu, MD, both physicians and Clinical Informatics Fellows at the Children’s Hospital of Philadelphia (CHOP). The Closing the Data Divide Virtual Challenge was jointly sponsored by the de Beaumont Foundation, which seeks to transform the practice of governmental public health, and the Practical Playbook, which works to increase collaboration between public health and primary care.

PHRASE is an electronic health record (EHR)-agnostic system designed to identify at-risk populations and provide clinical decision support to health care providers at the point of care. PHRASE allows for a two-way flow of data: public health provides timely updates about evolving disease and patient risk factors through the system, while clinicians consume these recommendations in the EHR and utilize one-click reporting of disease cases back to the public health department.

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Big Data Algorithm Aids Discovery of “DNA Scrunching”s

Philadelphia, March 4, 2016 - AA bioinformatics group from CHOP collaborated with researchers from Rutgers University to uncover details of an essential process in life: how a crucial enzyme locates the site on DNA where it begins to direct the synthesis of RNA.

"The algorithms we developed enable us to tackle many questions across diverse areas of DNA and RNA biology," said Deanne Taylor, PhD, director of bioinformatics in the Department of Biomedical and Health Informatics at CHOP and research assistant professor of Pediatrics at the University of Pennsylvania. "Understanding these fundamental processes may help in developing antimicrobial treatments to fight bacterial disease."

Dr. Taylor co-authored the study, which was published online this week in the journal Science.

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