Sharon Diskin, PhD
Assistant Professor of Pediatrics
Sharon's research is focused on understanding the genetic and genomic drivers of childhood cancers. A primary goal is to understand the complex interplay between germline and tumor genetics and their effect on tumorigenesis and treatment response. She is trained in computational cancer genomics and is studying the complex interplay between germline and tumor genetics and their effect on tumor initiation, progression and response to therapy. Her research program is inherently multi-disciplinary in that it couples integrative computational analyses of large scale data such as next generation sequencing, single nucleotide polymorphism (SNP) genotyping, mRNA, miRNA and lincRNA expression, epigenetic profiling, and DNA copy number data, with rigorous experimental validation defining how neuroblastoma-associated SNPs and copy number variations (CNVs) influence tumorigenesis and patient outcome and have recently identified LIN28B as a major oncogenic driver in neuroblastoma. In parallel to this, and as part of new project, her lab is investigating genetic susceptibility to treatment related comorbidities such as platinum-induced hearing loss. Sharon holds a BS in Computer Science from Villanova University and an MS in Computer Science and a PhD in Genomics and Computational Biology from the University of Pennsylvania.